Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells
المؤلفون المشاركون
Stéphane, Binet
Gaté, Laurent
Terzetti, F.
Coulais, C.
Fontana, C.
Guichard, Yves
Darne, Christian
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Carbon nanotubes (CNTs) belong to a specific class of nanomaterials with unique properties.
Because of their anticipated use in a wide range of industrial applications, their toxicity is of increasing concern.
In order to determine whether specific physicochemical characteristics of CNTs are responsible for their toxicological effects, we investigated the cytotoxic and genotoxic effects of eight CNTs representative of each of the commonly encountered classes: single- SW-, double- DW-, and multiwalled (MW) CNTs, purified and raw.
In addition, because most previous studies of CNT toxicity were conducted on immortalized cell lines, we decided to compare results obtained from V79 cells, an established cell line, with results from SHE (Syrian hamster embryo) cells, an easy-to-handle normal cell model.
After 24 hours of treatment, MWCNTs were generally found to be more cytotoxic than SW- or DWCNTs.
MWCNTs also provoked more genotoxic effects.
No correlation could be found between CNT genotoxicity and metal impurities, length, surface area, or induction of cellular oxidative stress, but genotoxicity was seen to increase with CNT width.
The toxicity observed for some CNTs leads us to suggest that they might also act by interfering with the cell cycle, but no significant differences were observed between normal and immortalized cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Darne, Christian& Terzetti, F.& Coulais, C.& Fontana, C.& Stéphane, Binet& Gaté, Laurent…[et al.]. 2014. Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043215
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Darne, Christian…[et al.]. Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells. Journal of Toxicology No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043215
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Darne, Christian& Terzetti, F.& Coulais, C.& Fontana, C.& Stéphane, Binet& Gaté, Laurent…[et al.]. Cytotoxicity and Genotoxicity of Panel of Single- and Multiwalled Carbon Nanotubes: In Vitro Effects on Normal Syrian Hamster Embryo and Immortalized V79 Hamster Lung Cells. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043215
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043215
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر