Three-Year Outcomes in Kidney Transplant Patients Randomized to Steroid-Free Immunosuppression or Steroid Withdrawal, with Enteric-Coated Mycophenolate Sodium and Cyclosporine: The Infinity Study
المؤلفون المشاركون
Kessler, M.
Kamar, Nassim
Thierry, A.
Büchler, M.
Choukroun, G.
Toupance, O.
Villemain, F.
Heng, A.-E.
Moulin, B.
Queré, S.
Di Giambattista, F.
Lecuyer, A.
Touchard, G.
Legendre, Christophe
Mourad, Georges
Merville, Pierre
Le Meur, Yannick
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In a six-month, multicenter, open-label trial, de novo kidney transplant recipients at low immunological risk were randomized to steroid avoidance or steroid withdrawal with IL-2 receptor antibody (IL-2RA) induction, enteric-coated mycophenolate sodium (EC-MPS: 2160 mg/day to week 6, 1440 mg/day thereafter), and cyclosporine.
Results from a 30-month observational follow-up study are presented.
Of 166 patients who completed the core study on treatment, 131 entered the follow-up study (70 steroid avoidance, 61 steroid withdrawal).
The primary efficacy endpoint of treatment failure (clinical biopsy-proven acute rejection (BPAR) graft loss, death, or loss to follow-up) occurred in 21.4% (95% CI 11.8–31.0%) of steroid avoidance patients and 16.4% (95% CI 7.1–25.7%) of steroid withdrawal patients by month 36 ( P = 0.46 ).
BPAR had occurred in 20.0% and 11.5%, respectively ( P = 0.19 ).
The incidence of adverse events with a suspected relation to steroids during months 6–36 was 22.9% versus 37.1% ( P = 0.062 ).
By month 36, 32.4% and 51.7% of patients in the steroid avoidance and steroid withdrawal groups, respectively, were receiving oral steroids.
In conclusion, IL-2RA induction with early intensified EC-MPS dosing and CNI therapy in de novo kidney transplant patients at low immunological risk may achieve similar three-year efficacy regardless of whether oral steroids are withheld for at least three months.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thierry, A.& Mourad, Georges& Büchler, M.& Choukroun, G.& Toupance, O.& Kamar, Nassim…[et al.]. 2014. Three-Year Outcomes in Kidney Transplant Patients Randomized to Steroid-Free Immunosuppression or Steroid Withdrawal, with Enteric-Coated Mycophenolate Sodium and Cyclosporine: The Infinity Study. Journal of Transplantation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043280
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thierry, A.…[et al.]. Three-Year Outcomes in Kidney Transplant Patients Randomized to Steroid-Free Immunosuppression or Steroid Withdrawal, with Enteric-Coated Mycophenolate Sodium and Cyclosporine: The Infinity Study. Journal of Transplantation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043280
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thierry, A.& Mourad, Georges& Büchler, M.& Choukroun, G.& Toupance, O.& Kamar, Nassim…[et al.]. Three-Year Outcomes in Kidney Transplant Patients Randomized to Steroid-Free Immunosuppression or Steroid Withdrawal, with Enteric-Coated Mycophenolate Sodium and Cyclosporine: The Infinity Study. Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043280
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043280
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر