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An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients
المؤلفون المشاركون
Esposito, Laure
Cardeau-Desangles, Isabelle
Kamar, Nassim
Pambrun, Emilie
Mengelle, Catherine
Fillola, Geneviève
Laharrague, Patrick
Rostaing, Lionel
Del Bello, Arnaud
Izopet, Jacques
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The human polyomavirus BK (BKV) is associated with severe complications, such as ureteric stenosis and polyomavirus-associated nephropathy (PVAN), which often occur in kidney-transplant patients.
However, it is unknown if BKV can replicate within bone marrow.
The aim of this study was to search for BKV replication within the bone marrow of kidney-transplant patients presenting with a hematological disorder.
Seventy-two kidney-transplant patients underwent bone-marrow aspiration for cytopenia.
At least one virus was detected in the bone marrow of 25/72 patients (35%), that is, parvovirus B19 alone (n = 8), parvovirus plus Epstein-Barr virus (EBV) (n = 3), cytomegalovirus (n = 4), EBV (n = 2), BKV alone (n = 7), and BKV plus EBV (n = 1).
Three of the eight patients who had BKV replication within the bone marrow had no detectable BKV replication in the blood.
Neutropenia was observed in all patients with BKV replication in the bone marrow, and blockade of granulocyte maturation was observed.
Hematological disorders disappeared in all patients after doses of immunosuppressants were reduced.
In conclusion, an association between BKV replication in bone marrow and hematological disorders, especially neutropenia, was observed.
Further studies are needed to confirm these findings.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pambrun, Emilie& Mengelle, Catherine& Fillola, Geneviève& Laharrague, Patrick& Esposito, Laure& Cardeau-Desangles, Isabelle…[et al.]. 2014. An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients. Journal of Transplantation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pambrun, Emilie…[et al.]. An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients. Journal of Transplantation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pambrun, Emilie& Mengelle, Catherine& Fillola, Geneviève& Laharrague, Patrick& Esposito, Laure& Cardeau-Desangles, Isabelle…[et al.]. An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients. Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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