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Alendronate as an Effective Treatment for Bone Loss and Vascular Calcification in Kidney Transplant Recipients
المؤلفون المشاركون
Okamoto, Masanori
Yamanaka, Shintaro
Yoshimoto, Wataru
Shigematsu, Takashi
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Kidney transplant recipients develop secondary osteoporosis induced by immunosuppressive medication, with a high risk of fracture, and abdominal aortic calcification (AC) is a known predictor of cardiovascular mortality.
In this study of 12 stable kidney recipients, we estimated the preventive effect of bisphosphonate treatment on bone loss and progression of AC.
We randomly divided the subjects into a treatment group with alendronate (group A: 5 subjects) and a control group (group C: 7 subjects).
Group A patients received 35 mg/week of alendronate over 24 months, while group C patients were not administered with any bisphosphonates.
Two major endpoints were established: (1) the time-dependent change in bone mineral density (BMD) estimated with DEXA and (2) progression of abdominal AC, calculated twice as an index (ACI) using computed tomography data.
Over the 2-year study period, group A patients showed significantly increased BMD of 1.86 ± 0.85% ( P = 0.015 versus baseline), and almost complete inhibition of ACI progression (38.2 ± 24.2% to 39.6 ± 24.3%), but group C patients showed a decrease in BMD decline with bone loss and progression of ACI (32.8 ± 25.0% to 37.8 ± 29.2%, P = 0.061 ).
In conclusion, alendronate therapy was an effective treatment in kidney transplant recipients for secondary osteoporosis and vascular calcification as ectopic calcification.
This clinical trial is registered with number JMA-IIA00155 of JMACCT CTR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okamoto, Masanori& Yamanaka, Shintaro& Yoshimoto, Wataru& Shigematsu, Takashi. 2014. Alendronate as an Effective Treatment for Bone Loss and Vascular Calcification in Kidney Transplant Recipients. Journal of Transplantation،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043284
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okamoto, Masanori…[et al.]. Alendronate as an Effective Treatment for Bone Loss and Vascular Calcification in Kidney Transplant Recipients. Journal of Transplantation No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1043284
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okamoto, Masanori& Yamanaka, Shintaro& Yoshimoto, Wataru& Shigematsu, Takashi. Alendronate as an Effective Treatment for Bone Loss and Vascular Calcification in Kidney Transplant Recipients. Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1043284
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043284
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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