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Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation
المؤلفون المشاركون
Lindås, Roald
Tvedt, Tor Henrik Andersson
Hatfield, Kimberley Joanne
Reikvam, Håkon
Bruserud, Øystein
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation.
These cells express several molecules that can be detected as biologically active soluble forms; serum levels of these molecules may thereby reflect the functional status of endothelial cells.
Furthermore, acute GVHD is an inflammatory reaction and endothelial cells function as local regulators of inflammation.
We therefore investigated whether differences in preconditioning/pretransplant serum levels of endothelium-expressed molecules (i.e., endocan, vascular cell adhesion molecule 1 (VCAM-1), and E-selectin) were associated with a risk of posttransplant GVHD.
Our study should be regarded as a population-based study of consecutive and thereby unselected patients ( n = 56 ).
Analysis of this pretreatment endothelium biomarker profile by unsupervised hierarchical clustering identified a subset of patients with increased early nonrelapse mortality.
Furthermore, low endocan levels were significantly associated with acute GVHD in the liver and gastrointestinal tract, whereas high VCAM-1 levels were associated with acute GVHD in the skin only.
Our study suggests that the preconditioning/pretransplant status of endothelial cells (possibly through altered trafficking of immunocompetent cells) is important for the risk and the organ involvement of later acute GVHD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lindås, Roald& Tvedt, Tor Henrik Andersson& Hatfield, Kimberley Joanne& Reikvam, Håkon& Bruserud, Øystein. 2014. Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation. Journal of Transplantation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043290
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lindås, Roald…[et al.]. Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation. Journal of Transplantation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043290
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lindås, Roald& Tvedt, Tor Henrik Andersson& Hatfield, Kimberley Joanne& Reikvam, Håkon& Bruserud, Øystein. Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell Transplantation. Journal of Transplantation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043290
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043290
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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