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5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils
المؤلفون المشاركون
Xavier-Elsas, P.
Masid-de-Brito, D.
Luz, R. A.
Gaspar-Elsas, M. I.
de Luca, Bianca
Cauduro, Priscila Soares
Gondar Arcanjo, Luiz Carlos
Cordeiro Faria dos Santos, Ana Carolina
de Oliveira, Ivi Cristina Maria
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The roles of eosinophils in antimicrobial defense remain incompletely understood.
In ovalbumin-sensitized mice, eosinophils are selectively recruited to the peritoneal cavity by antigen, eotaxin, or leukotriene(LT)B4, a 5-lipoxygenase (5-LO) metabolite.
5-LO blockade prevents responses to both antigen and eotaxin.
We examined responses to eotaxin in the absence of sensitization and their dependence on 5-LO.
BALB/c or PAS mice and their mutants (5-LO-deficient ALOX; eosinophil-deficient GATA-1) were injected i.p.
with eotaxin, eosinophils, or both, and leukocyte accumulation was quantified up to 24 h.
Significant recruitment of eosinophils by eotaxin in BALB/c, up to 24 h, was accompanied by much larger numbers of recruited neutrophils and monocytes/macrophages.
These effects were abolished by eotaxin neutralization and 5-LO-activating protein inhibitor MK886.
In ALOX (but not PAS) mice, eotaxin recruitment was abolished for eosinophils and halved for neutrophils.
In GATA-1 mutants, eotaxin recruited neither neutrophils nor macrophages.
Transfer of eosinophils cultured from bone-marrow of BALB/c donors, or from ALOX donors, into GATA-1 mutant recipients, i.p., restored eotaxin recruitment of neutrophils and showed that the critical step dependent on 5-LO is the initial recruitment of eosinophils by eotaxin, not the secondary neutrophil accumulation.
Eosinophil-dependent recruitment of neutrophils in naive BALB/c mice was associated with increased binding of bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luz, R. A.& Xavier-Elsas, P.& de Luca, Bianca& Masid-de-Brito, D.& Cauduro, Priscila Soares& Gondar Arcanjo, Luiz Carlos…[et al.]. 2014. 5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043305
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luz, R. A.…[et al.]. 5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043305
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luz, R. A.& Xavier-Elsas, P.& de Luca, Bianca& Masid-de-Brito, D.& Cauduro, Priscila Soares& Gondar Arcanjo, Luiz Carlos…[et al.]. 5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043305
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043305
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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