The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease

المؤلفون المشاركون

Li, Yanmei
Wang, Yanan
Liu, Ying
Wang, Yatian
Zuo, Xiuli
Li, Yanqing
Lu, Xuefeng

المصدر

Mediators of Inflammation

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-18

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض

الملخص EN

Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines.

They have been described in inflammatory diseases such as collagen-induced arthritis and asthma.

However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored.

Our aim was to evaluate serum and inflamed mucosal levels in IBD patients.

In 20 ulcerative colitis (UC) patients, 7 Crohn’s disease (CD) patients, and 15 healthy subjects, cytokine levels in serum were determined using ELISA and mucosal expression studies were performed by immunohistochemistry, quantitative real-time PCR, and Western blot.

The results showed that serums IL-35 and IL-37 levels were significantly decreased in UC and CD patients compared with healthy subjects.

The cytokines levels correlated inversely with UC activity.

IL-35 was expressed in infiltrating immune cells while IL-37 in intestinal epithelial cells as well as inflammatory cells.

IBD patients had significantly higher Ebi3, p35 (two subunits of IL-35), and IL-37b gene expressions; IL-35 and IL-37 protein expressions were higher in IBD patients compared with controls.

The study showed that serums IL-35 and IL-37 might be potentially novel biomarkers for IBD.

Intestinal IL-35 and IL-37 proteins are upregulated, suggesting that regulating the expression of the two cytokines may provide a new possible target for the treatment of IBD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Yanmei& Wang, Yanan& Liu, Ying& Wang, Yatian& Zuo, Xiuli& Li, Yanqing…[et al.]. 2014. The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043336

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Yanmei…[et al.]. The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043336

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Yanmei& Wang, Yanan& Liu, Ying& Wang, Yatian& Zuo, Xiuli& Li, Yanqing…[et al.]. The Possible Role of the Novel Cytokines IL-35 and IL-37 in Inflammatory Bowel Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043336

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1043336