![](/images/graphics-bg.png)
Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury
المؤلفون المشاركون
Akbarshahi, Hamid
Sam, Asha
Chen, Chaolei
Rosendahl, Ann H.
Andersson, Roland
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Acute lung injury is caused by many factors including acute pancreatitis.
There is no specific therapy directed at underlying pathophysiological mechanisms for acute lung injury.
Transforming growth factor-β (TGF-β) is involved in the resolution of lung injury in later phases of the disease.
Some evidence exists demonstrating that TGF-β not only is involved in the late stages, but also contributes to lung injury early on in the progress of the disease.
Acute pancreatitis was induced using ductal ligation in mice.
TGF-β1, 2, and 3, TβRII, ALK-5, Smad2, 3, 4, and 7, and P-Smad2 expression in the lungs were analyzed at 9 and 24 h.
We demonstrate that TGF-β1 levels in the lungs of mice with acute pancreatitis increase as early as 9 h after induction.
We observed an increased expression of ALK-5 in acute pancreatitis at both 9 and 24 h.
Inhibitory Smad7 expression was transiently increased at 9 h in acute pancreatitis, but reduced later at 24 h, with a concomitant increased nuclear translocation of phosphorylated Smad2.
Our findings demonstrate activation of TGF-β signaling in the lungs as early as 24 h after acute pancreatitis, suggesting that TGF-β may represent a potential therapeutic candidate in acute pancreatitis-induced acute lung injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akbarshahi, Hamid& Sam, Asha& Chen, Chaolei& Rosendahl, Ann H.& Andersson, Roland. 2014. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akbarshahi, Hamid…[et al.]. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akbarshahi, Hamid& Sam, Asha& Chen, Chaolei& Rosendahl, Ann H.& Andersson, Roland. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)