Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury
Joint Authors
Akbarshahi, Hamid
Sam, Asha
Chen, Chaolei
Rosendahl, Ann H.
Andersson, Roland
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acute lung injury is caused by many factors including acute pancreatitis.
There is no specific therapy directed at underlying pathophysiological mechanisms for acute lung injury.
Transforming growth factor-β (TGF-β) is involved in the resolution of lung injury in later phases of the disease.
Some evidence exists demonstrating that TGF-β not only is involved in the late stages, but also contributes to lung injury early on in the progress of the disease.
Acute pancreatitis was induced using ductal ligation in mice.
TGF-β1, 2, and 3, TβRII, ALK-5, Smad2, 3, 4, and 7, and P-Smad2 expression in the lungs were analyzed at 9 and 24 h.
We demonstrate that TGF-β1 levels in the lungs of mice with acute pancreatitis increase as early as 9 h after induction.
We observed an increased expression of ALK-5 in acute pancreatitis at both 9 and 24 h.
Inhibitory Smad7 expression was transiently increased at 9 h in acute pancreatitis, but reduced later at 24 h, with a concomitant increased nuclear translocation of phosphorylated Smad2.
Our findings demonstrate activation of TGF-β signaling in the lungs as early as 24 h after acute pancreatitis, suggesting that TGF-β may represent a potential therapeutic candidate in acute pancreatitis-induced acute lung injury.
American Psychological Association (APA)
Akbarshahi, Hamid& Sam, Asha& Chen, Chaolei& Rosendahl, Ann H.& Andersson, Roland. 2014. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
Modern Language Association (MLA)
Akbarshahi, Hamid…[et al.]. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
American Medical Association (AMA)
Akbarshahi, Hamid& Sam, Asha& Chen, Chaolei& Rosendahl, Ann H.& Andersson, Roland. Early Activation of Pulmonary TGF-β1Smad2 Signaling in Mice with Acute Pancreatitis-Associated Acute Lung Injury. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043346