![](/images/graphics-bg.png)
Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis
المؤلفون المشاركون
Vidal, Bruno
Raquel, Helena
Neves-Costa, Ana
Figueiredo, Nuno
Gupta, Vineet
Ferreira Moita, Luis
Fonseca, Joao Eurico
Cascão, R.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA).
These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early RA treatment.
We have recently identified gambogic acid as a promising therapeutic candidate to simultaneously block IL-1β and TNF secretion.
Our main goal here was to investigate whether gambogic acid administration was able to attenuate inflammation in antigen-induced arthritis (AIA) rats.
Methods.
Gambogic acid was administered to AIA rats in the early and late phases of arthritis.
The inflammatory score, ankle perimeter, and body weight were evaluated during the period of treatment.
Rats were sacrificed after 19 days of disease progression and paw samples were collected for histological and immunohistochemical evaluation.
Results.
We found that inflammation in joints was significantly suppressed following gambogic acid administration.
Histological and immunohistochemical evaluation of treated rats revealed normal joint structures with complete abrogation of the inflammatory infiltrate and cellular proliferation.
Conclusions.
Our results suggest that gambogic acid has significant anti-inflammatory properties and can possibly constitute a prototype anti-inflammatory drug with therapeutic efficacy in the treatment of inflammatory diseases such as RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cascão, R.& Vidal, Bruno& Raquel, Helena& Neves-Costa, Ana& Figueiredo, Nuno& Gupta, Vineet…[et al.]. 2014. Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043371
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cascão, R.…[et al.]. Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043371
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cascão, R.& Vidal, Bruno& Raquel, Helena& Neves-Costa, Ana& Figueiredo, Nuno& Gupta, Vineet…[et al.]. Potent Anti-Inflammatory and Antiproliferative Effects of Gambogic Acid in a Rat Model of Antigen-Induced Arthritis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043371
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043371
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)