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Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen
المؤلفون المشاركون
Pádua, Bruno da Cruz
Rossoni Júnior, Joamyr Victor
de Brito Magalhães, Cíntia Lopes
Chaves, Míriam Martins
Silva, Marcelo Eustáquio
Pedrosa, Maria Lucia
Souza, Gustavo Henrique Bianco de
Brandão, Geraldo Célio
Rodrigues, Ivanildes Vasconcelos
Lima, Wanderson Geraldo
Costa, Daniela Caldeira
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Acetaminophen (APAP) is a commonly used analgesic and antipyretic.
When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure.
Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.
Methods.
The present study attempted to investigate the protective effect of B.
trimera against APAP-induced hepatic damage in rats.
The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined.
Results.
The pretreatment with B.
trimera attenuated serum activities of ALT and AST that were enhanced by administration of APAP.
Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione.
Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP.
Conclusions.
The hepatoprotective action of B.
trimera extract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model.
General Significance.
These results make the extract of B.
trimera a potential candidate drug capable of protecting the liver against damage caused by APAP overdose.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pádua, Bruno da Cruz& Rossoni Júnior, Joamyr Victor& de Brito Magalhães, Cíntia Lopes& Chaves, Míriam Martins& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia…[et al.]. 2014. Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pádua, Bruno da Cruz…[et al.]. Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pádua, Bruno da Cruz& Rossoni Júnior, Joamyr Victor& de Brito Magalhães, Cíntia Lopes& Chaves, Míriam Martins& Silva, Marcelo Eustáquio& Pedrosa, Maria Lucia…[et al.]. Protective Effect of Baccharis trimera Extract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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