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Novel Insights into miRNA in Lung and Heart Inflammatory Diseases
المؤلفون المشاركون
Petrkova, Jana
Petrek, Martin
Kishore, Amit
Borucka, Jana
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-27، 27ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-27
دولة النشر
مصر
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) are noncoding regulatory sequences that govern posttranscriptional inhibition of genes through binding mainly at regulatory regions.
The regulatory mechanism of miRNAs are influenced by complex crosstalk among single nucleotide polymorphisms (SNPs) within miRNA seed region and epigenetic modifications.
Circulating miRNAs exhibit potential characteristics as stable biomarker.
Functionally, miRNAs are involved in basic regulatory mechanisms of cells including inflammation.
Thus, miRNA dysregulation, resulting in aberrant expression of a gene, is suggested to play an important role in disease susceptibility.
This review focuses on the role of miRNA as diagnostic marker in pathogenesis of lung inflammatory diseases and in cardiac remodelling events during inflammation.
From recent reports, In this context, the information about the models in which miRNAs expression were investigated including types of biological samples, as well as on the methods for miRNA validation and prediction/definition of their gene targets are emphasized in the review.
Besides disease pathogenesis, promising role of miRNAs in early disease diagnosis and prognostication is also discussed.
However, some miRNAs are also indicated with protective role.
Thus, identifications and usage of such potential miRNAs as well as disruption of disease susceptible miRNAs using antagonists, antagomirs, are imperative and may provide a novel therapeutic approach towards combating the disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kishore, Amit& Borucka, Jana& Petrkova, Jana& Petrek, Martin. 2014. Novel Insights into miRNA in Lung and Heart Inflammatory Diseases. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1043407
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kishore, Amit…[et al.]. Novel Insights into miRNA in Lung and Heart Inflammatory Diseases. Mediators of Inflammation No. 2014 (2014), pp.1-27.
https://search.emarefa.net/detail/BIM-1043407
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kishore, Amit& Borucka, Jana& Petrkova, Jana& Petrek, Martin. Novel Insights into miRNA in Lung and Heart Inflammatory Diseases. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1043407
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043407
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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