Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALBc Mice
المؤلفون المشاركون
Ku, Jin Mo
Choi, Han-Seok
Ko, Seong-Gyu
Kim, Soon Re
Shin, Yong Cheol
Hong, Se Hyang
Seo, Hye-Sook
Yoo, Hye Hyun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
CP001 is four traditional herbal medicine mixtures with anti-inflammatory properties.
In this study, we investigated the effect of oral administration of CP001 ethanol extract on the 2,4-dinitrochlorobenzene- (DNCB-) induced AD mouse models.
For that purpose, we observed the effects of oral administration of CP001 on skin inflammatory cell infiltration, skin mast cells, production of serum IgE, and expression of Th2 cytokine mRNA in the AD skin lesions of DNCB treated BALB/c mice.
Histological analyses demonstrated that CP001 decreased dermis and epidermis thickening as well as dermal infiltration induced by inflammatory cells.
In addition, CP001 decreased mast cell infiltration in count as well as dermal infiltration induced by inflammatory cells.
In the skin lesions, mRNA expression of interleukin- (IL-) 4 and IL-13 was inhibited by CP001.
CP001 also reduced the production of IgE level in mouse plasma.
In addition, we investigated the effect of CP001 on the inflammatory allergic reaction using human mast cells (HMC-1).
In HMC-1, cytokine production and mRNA levels of IL-4, IL-13, IL-6, and IL-8 were suppressed by CP001.
Taken together, our results showed that oral administration of CP001 exerts beneficial effects in AD symptoms, suggesting that CP001 might be a useful candidate for the treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Soon Re& Choi, Han-Seok& Seo, Hye-Sook& Ku, Jin Mo& Hong, Se Hyang& Yoo, Hye Hyun…[et al.]. 2014. Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALBc Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Soon Re…[et al.]. Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALBc Mice. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Soon Re& Choi, Han-Seok& Seo, Hye-Sook& Ku, Jin Mo& Hong, Se Hyang& Yoo, Hye Hyun…[et al.]. Oral Administration of Herbal Mixture Extract Inhibits 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in BALBc Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر