Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17Treg Balance, and Osteoclastogenesis in Mice and Human
المؤلفون المشاركون
Park, Sung-Hwan
Ju, Ji Hyeon
Jhun, JooYeon
Lee, Jennifer
Byun, Jae-Kyeong
Kim, Eun-Kyung
Woo, Jung-Won
Lee, Jae-Ho
Park, Kyung-Su
Kim, Ho-Youn
Cho, Mi-La
Kwok, Seung-Ki
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation.
Red ginseng is a steamed and dried Panax ginseng C.A.
Meyer, which has been used as alternative medicine for thousands of years.
This study was undertaken to investigate the effects of red ginseng extracts (RGE) on autoimmune arthritis in mice and humans and to delineate the underlying mechanism.
RGE was orally administered three times a week to mice with arthritis.
Oral administration of RGE markedly ameliorated clinical arthritis score and histologically assessed joint inflammation in mice with CIA.
A significant reduction in STAT3 phosphorylation and a decrease in the number of Th17 cells were observed with RGE treatment.
There was also a marked reduction in RANKL-induced osteoclastogenesis with treatment of RGE.
The inhibitory effect of RGE on Th17 differentiation and osteoclastogenesis observed in mice was also confirmed in the subsequent experiments performed using human peripheral blood mononuclear cells.
Our findings provide the first evidence that RGE can regulate Th17 and reciprocally promote Treg cells by inhibiting the phosphorylation of STAT3.
Therefore, RGE can ameliorate arthritis in mice with CIA by targeting pathogenic Th17 and osteoclast differentiation, suggesting a novel therapy for treatment of RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jhun, JooYeon& Lee, Jennifer& Byun, Jae-Kyeong& Kim, Eun-Kyung& Woo, Jung-Won& Lee, Jae-Ho…[et al.]. 2014. Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17Treg Balance, and Osteoclastogenesis in Mice and Human. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jhun, JooYeon…[et al.]. Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17Treg Balance, and Osteoclastogenesis in Mice and Human. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jhun, JooYeon& Lee, Jennifer& Byun, Jae-Kyeong& Kim, Eun-Kyung& Woo, Jung-Won& Lee, Jae-Ho…[et al.]. Red Ginseng Extract Ameliorates Autoimmune Arthritis via Regulation of STAT3 Pathway, Th17Treg Balance, and Osteoclastogenesis in Mice and Human. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر