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NF-κBAP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton
المؤلفون المشاركون
Yang, Woo Seok
Shin, Song Seok
Kim, Eunji
Baek, Heung Soo
Baek, Gwang-Soo
Yang, Sungjae
Ha, Van Thai
Hossen, Muhammad Jahangir
Kim, Yong
Kim, Jun Ho
Kim, Jeong-Hwan
Joo, Yung Hyup
Lee, Chang Seok
Choi, Joonho
Shin, Hong-Ju
Cho, Jae Youl
Hong, Sungyoul
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression.
Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736.
The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.7 cells.
AP736 was found to strongly inhibit the production of both NO and PGE2 in lipopolysaccharide- (LPS-) treated RAW264.7 cells.
In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake.
Furthermore, AP736 also downregulated the expression of multiple inflammatory genes, such as inducible NO synthase (iNOS), cyclooxygenase- (COX-) 2, and interleukin- (IL-) 1β in LPS-treated RAW264.7 cells.
Transcription factor analysis, including upstream signalling events, revealed that both NF-κB and AP-1 were targeted by AP736 via inhibition of the IKK/IκBα and IRAK1/TAK1 pathways.
Therefore, our results strongly suggest that AP736 is a potential anti-inflammatory drug due to its suppression of NF-κB-IKK/IκBα and AP-1-IRAK1/TAK1 signalling, which may make AP736 useful for the treatment of macrophage-mediated skin inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ha, Van Thai& Baek, Heung Soo& Kim, Eunji& Baek, Gwang-Soo& Hossen, Muhammad Jahangir& Yang, Woo Seok…[et al.]. 2014. NF-κBAP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043502
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ha, Van Thai…[et al.]. NF-κBAP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043502
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ha, Van Thai& Baek, Heung Soo& Kim, Eunji& Baek, Gwang-Soo& Hossen, Muhammad Jahangir& Yang, Woo Seok…[et al.]. NF-κBAP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043502
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043502
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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