Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral IschemiaReperfusion in Mice
المؤلفون المشاركون
Zhang, Nan
Zhang, Xiangjian
Liu, Xiaoxia
Wang, Hong
Xue, Jing
Yu, Jingying
Kang, Ning
Wang, Xiaolu
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The most effective way to contain cerebral ischemic injury is reperfusion; however, reperfusion itself may result in tissue injury, for which inflammatory damage is one of the main causative factors.
NALP3 inflammasome is a multiprotein complex.
It consists of NALP3, ASC, and caspase-1, whose function is to switch on the inflammatory process.
Chrysophanol is an extract from plants of Rheum genus and it possesses many pharmacological effects including its anti-inflammation activity.
In this study, the effects of chrysophanol in cerebral ischemia/reperfusion and the potential mechanisms were investigated.
Male CD1 mice were subject to transient middle cerebral artery occlusion (tMCAO).
The NALP3 inflammasome activation status and its dynamic expression during the natural inflammatory response induced by tMCAO were first profiled.
The neuroprotective effects of chrysophanol were then assessed and the potential mechanisms mediating the observed neuroprotection were then explored.
Physical parameters including neurological deficit, infarct size, brain edema, and BBB permeability were measured at 24 h after tMCAO.
Confocal microscopy, Western blotting, immunohistochemistry, and qRT-PCR techniques were utilized to analyze the expression of NALP3 inflammasome and IL-1β.
Our results indicated that the brain tissue damage during cerebral ischemia/reperfusion is accompanied by NALP3 inflammasome activation.
Chrysophanol could inhibit the activation of NALP3 inflammasome and protect cerebral ischemic stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Nan& Zhang, Xiangjian& Liu, Xiaoxia& Wang, Hong& Xue, Jing& Yu, Jingying…[et al.]. 2014. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral IschemiaReperfusion in Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043509
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Nan…[et al.]. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral IschemiaReperfusion in Mice. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043509
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Nan& Zhang, Xiangjian& Liu, Xiaoxia& Wang, Hong& Xue, Jing& Yu, Jingying…[et al.]. Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral IschemiaReperfusion in Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043509
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043509
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر