Brain-Derived Neurotrophic Factor in Chronic Periodontitis

المؤلفون المشاركون

Silva, Tarcília Aparecida da
Queiroz-Junior, Celso Martins
Pereira, Daniele Sirineu
Souza, Danielle Glória
Costa, José Eustáquio
Teixeira, Mauro Martins
Madeira, Mila Fernandes Moreira
Corrêa, Jôice Dias
Teixeira, Antonio Lucio

المصدر

Mediators of Inflammation

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-12-21

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family.

Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts.

Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied.

The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC).

All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms.

Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects.

BDNF levels were increased in CP patients compared to HC subjects.

A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium.

No differences in frequencies of BDNF genotypes between CP and HC subjects were observed.

However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients.

In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Corrêa, Jôice Dias& Pereira, Daniele Sirineu& Madeira, Mila Fernandes Moreira& Queiroz-Junior, Celso Martins& Souza, Danielle Glória& Teixeira, Mauro Martins…[et al.]. 2014. Brain-Derived Neurotrophic Factor in Chronic Periodontitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043510

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Corrêa, Jôice Dias…[et al.]. Brain-Derived Neurotrophic Factor in Chronic Periodontitis. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043510

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Corrêa, Jôice Dias& Pereira, Daniele Sirineu& Madeira, Mila Fernandes Moreira& Queiroz-Junior, Celso Martins& Souza, Danielle Glória& Teixeira, Mauro Martins…[et al.]. Brain-Derived Neurotrophic Factor in Chronic Periodontitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043510

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1043510