![](/images/graphics-bg.png)
Clinical Value of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Term Neonates with Infection or Sepsis: A Prospective Study
المؤلفون المشاركون
Papassotiriou, Ioannis
Siahanidou, Tania
Tsirogianni, Chrysanthi
Charoni, Stavroula
Giannaki, Maria
Vavourakis, Eustathios
Charisiadou, Athina
Margeli, Alexandra
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
suPAR, the soluble form of the urokinase-type plasminogen activator receptor, has been identified as a biomarker of infection in adults but its properties in neonatal infection are not known.
Methods.
Plasma suPAR levels were determined by ELISA in 47 term neonates with infection (19 bacterial and 28 viral) and in 18 healthy neonates as controls.
Thirteen out of 47 infected neonates were septic.
In all infected neonates, suPAR levels were repeated at 24 hours, 48 hours, 3–5 days, and 7–10 days following admission.
Results.
Plasma suPAR levels were significantly increased in infected neonates upon admission, whereas they were highest in septic neonates, in comparison with controls P < 0.001 and correlated positively with serum CRP levels ( P = 0.001 ).
At infection subsidence, suPAR concentrations decreased significantly in comparison with baseline ( P < 0.001 ) but remained higher than in controls ( P = 0.01 ).
Receiver operating characteristic analysis resulted in significant areas under the curve for detecting either infected or septic neonates, but not for discriminating between bacterial and viral cause of infection.
Conclusions.
suPAR is a diagnostic biomarker of infection or sepsis in term neonates; however, it cannot discriminate bacterial from viral infections and also its utility for monitoring the response to treatment is questioned.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Siahanidou, Tania& Margeli, Alexandra& Tsirogianni, Chrysanthi& Charoni, Stavroula& Giannaki, Maria& Vavourakis, Eustathios…[et al.]. 2014. Clinical Value of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Term Neonates with Infection or Sepsis: A Prospective Study. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Siahanidou, Tania…[et al.]. Clinical Value of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Term Neonates with Infection or Sepsis: A Prospective Study. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Siahanidou, Tania& Margeli, Alexandra& Tsirogianni, Chrysanthi& Charoni, Stavroula& Giannaki, Maria& Vavourakis, Eustathios…[et al.]. Clinical Value of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Term Neonates with Infection or Sepsis: A Prospective Study. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)