Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages
المؤلفون المشاركون
Chen, Yuanyuan
Luo, Guangyan
Yuan, Jiao
Wang, Yuanyuan
Yang, Xiaoqiong
Wang, Xiaoyun
Li, Guoping
Liu, Zhiguang
Zhong, Nanshan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oxidative stress is an important part of host innate immune response to foreign pathogens.
However, the impact of vitamin C on oxidative stress and inflammation remains unclear in community-acquired pneumonia (CAP).
We aimed to determine the effect of vitamin C on oxidative stress and inflammation.
CAP patients were enrolled.
Reactive oxygen species (ROS), DNA damage, superoxide dismutases (SOD) activity, tumor necrosis factor-alpha (TNF-α), and IL-6 were analyzed in CAP patients and LPS-stimulated macrophages cells.
MH-S cells were transfected with RFP-LC3 plasmids.
Autophagy was measured in LPS-stimulated macrophages cells.
Severe CAP patients showed significantly increased ROS, DNA damage, TNF-α, and IL-6.
SOD was significantly decreased in severe CAP.
Vitamin C significantly decreased ROS, DNA damage, TNF-α, and IL-6.
Vitamin C inhibited LPS-induced ROS, DNA damage, TNF-α, IL-6, and p38 in macrophages cells.
Vitamin C inhibited autophagy in LPS-induced macrophages cells.
These findings indicated that severe CAP exhibited significantly increased oxidative stress, DNA damage, and proinflammatory mediator.
Vitamin C mitigated oxidative stress and proinflammatory mediator suggesting a possible mechanism for vitamin C in severe CAP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yuanyuan& Luo, Guangyan& Yuan, Jiao& Wang, Yuanyuan& Yang, Xiaoqiong& Wang, Xiaoyun…[et al.]. 2014. Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yuanyuan…[et al.]. Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yuanyuan& Luo, Guangyan& Yuan, Jiao& Wang, Yuanyuan& Yang, Xiaoqiong& Wang, Xiaoyun…[et al.]. Vitamin C Mitigates Oxidative Stress and Tumor Necrosis Factor-Alpha in Severe Community-Acquired Pneumonia and LPS-Induced Macrophages. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر