Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma
المؤلفون المشاركون
Roh, Hwan-Jung
Cho, Kyu-Sup
Park, Mi-Kyung
Kang, Shin-Ae
Park, Hee-Young
Hong, Sung-Lyong
Park, Hye-Kyung
Yu, Hak Sun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Although several studies have demonstrated that mesenchymal stem cells derived from adipose tissue (ASCs) can ameliorate allergic airway inflammation, the immunomodulatory mechanism of ASCs remains unclear.
In this study, we investigated whether regulatory T cells (Tregs) induction is a potential mechanism in immunomodulatory effects of ASCs on allergic airway disease and how these induced Tregs orchestrate allergic inflammation.
Intravenous administration of ASCs significantly reduced allergic symptoms and inhibited eosinophilic inflammation.
Airway hyperresponsiveness, total immune cell and eosinophils in the bronchoalveolar lavage fluid, mucus production, and serum allergen-specific IgE and IgG1 were significantly reduced after ASCs administration.
ASCs significantly inhibited Th2 cytokines (IL-4, IL-5, and IL-13) and enhanced Th1 cytokine (IFN-γ) and regulatory cytokines (IL-10 and TGF-β) in the bronchoalveolar lavage fluid and lung draining lymph nodes.
Furthermore, levels of IDO, TGF-β, and PGE2 were significantly increased after ASCs administration.
Interestingly, this upregulation was accompanied by increased Treg populations.
In conclusion, ASCs ameliorated allergic airway inflammation and improved lung function through the induction of Treg expansion.
The induction of Treg by ASCs involves the secretion of soluble factors such as IDO, TGF-β, and PGE2 and Treg might be involved in the downregulation of Th2 cytokines and upregulation of Th1 cytokines production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cho, Kyu-Sup& Park, Mi-Kyung& Kang, Shin-Ae& Park, Hee-Young& Hong, Sung-Lyong& Park, Hye-Kyung…[et al.]. 2014. Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cho, Kyu-Sup…[et al.]. Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cho, Kyu-Sup& Park, Mi-Kyung& Kang, Shin-Ae& Park, Hee-Young& Hong, Sung-Lyong& Park, Hye-Kyung…[et al.]. Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر