Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3KAkt Pathway
المؤلفون المشاركون
Gui, Bo
Chen, Jie
Xu, Zeping
Sun, Hongbin
Qian, Yanning
Hua, Fuzhou
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-16
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Oleanolic acid (OA) has been used to treat liver disorders, but whether it can attenuate hepatic ischemia-reperfusion- (IR-) associated liver dysfunction remains unexplored.
In the present study, 160 male Sprague-Dawley rats were equally divided into five groups: group SH received neither hepatic IR nor drugs; group IR received hepatic IR without drugs; group CM and group OA received 0.5% sodium carboxymethylcellulose and 100 mg/kg OA, intragastrically, once a day for seven days before the hepatic IR, respectively; on the basis of treatment in group OA, group OA+wortmannin further received 15 μ g/kg of PI3K inhibitor wortmannin, intraperitoneally, 30 min before the hepatic IR.
Then each group was equally divided into four subgroups according to four time points (preoperation, 0 h, 3 h, and 6 h after reperfusion).
Serum ALT activity, IL-1 β concentration, and hepatic phosphorylation of PI3K, Akt, and GSK-3 β protein expression were serially studied.
We found that OA pretreatment improved histological status and decreased serum ALT and IL-1 β levels.
It also increased p-PI3K, p-Akt, and p-GSK-3 β protein expression at all the four time points.
Prophylactic wortmannin partially reversed OA’s protective effects.
The data indicate that OA pretreatment protects liver from IR injury during the acute phase partially through PI3K/Akt-mediated inactivation of GSK-3 β .
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gui, Bo& Hua, Fuzhou& Chen, Jie& Xu, Zeping& Sun, Hongbin& Qian, Yanning. 2014. Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3KAkt Pathway. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gui, Bo…[et al.]. Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3KAkt Pathway. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gui, Bo& Hua, Fuzhou& Chen, Jie& Xu, Zeping& Sun, Hongbin& Qian, Yanning. Protective Effects of Pretreatment with Oleanolic Acid in Rats in the Acute Phase of Hepatic Ischemia-Reperfusion Injury: Role of the PI3KAkt Pathway. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر