Dynamics of Acute Local Inflammatory Response after Autologous Transplantation of Muscle-Derived Cells into the Skeletal Muscle
المؤلفون المشاركون
Burdzinska, Anna
Gala, Kamila
Kowalewski, Cezary
Zagozdzon, Radosław
Gajewski, Zdzisław
Pączek, Leszek
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The vast majority of myoblasts transplanted into the skeletal muscle die within the first week after injection.
Inflammatory response to the intramuscular cell transfer was studied in allogeneic but not in autologous model.
The aim of this study was to evaluate immune reaction to autotransplantation of myogenic cells and to assess its dynamics within the first week after injection.
Muscle-derived cells or medium alone was injected into the intact skeletal muscles in autologous model.
Tissue samples were collected 1, 3, and 7 days after the procedure.
Our analysis revealed the peak increase of the gene expression of all evaluated cytokines (Il-1α, Il-1β, Il-6, Tgf-β, and Tnf-α) at day 1.
The mRNA level of analyzed cytokines normalized in subsequent time points.
The increase of Il-β gene expression was further confirmed at the protein level.
Analysis of the tissue sections revealed rapid infiltration of injected cell clusters with neutrophils and macrophages.
The inflammatory infiltration was almost completely resolved at day 7.
The survived cells were able to participate in the muscle regeneration process.
Presented results demonstrate that autotransplanted muscle-derived cells induce classical early immune reaction in the site of injection which may contribute to cellular graft elimination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burdzinska, Anna& Gala, Kamila& Kowalewski, Cezary& Zagozdzon, Radosław& Gajewski, Zdzisław& Pączek, Leszek. 2014. Dynamics of Acute Local Inflammatory Response after Autologous Transplantation of Muscle-Derived Cells into the Skeletal Muscle. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043593
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burdzinska, Anna…[et al.]. Dynamics of Acute Local Inflammatory Response after Autologous Transplantation of Muscle-Derived Cells into the Skeletal Muscle. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043593
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burdzinska, Anna& Gala, Kamila& Kowalewski, Cezary& Zagozdzon, Radosław& Gajewski, Zdzisław& Pączek, Leszek. Dynamics of Acute Local Inflammatory Response after Autologous Transplantation of Muscle-Derived Cells into the Skeletal Muscle. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043593
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043593
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر