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Long-Term Home Noninvasive Mechanical Ventilation Increases Systemic Inflammatory Response in Chronic Obstructive Pulmonary Disease: A Prospective Observational Study
المؤلفون المشاركون
Paone, Gregorino
De Falco, Elena
Chimenti, Isotta
Peruzzi, Mariangela
Frati, Giacomo
Biondi-Zoccai, Giuseppe
Mollica, Corrado
Monaco, Gianluca
Giannunzio, Gilda
Brunetti, Giuseppe
Schmid, Giovanni
Ranieri, V. Marco
Conti, Vittoria
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Long-term home noninvasive mechanical ventilation (NIV) is beneficial in COPD but its impact on inflammation is unknown.
We assessed the hypothesis that NIV modulates systemic and pulmonary inflammatory biomarkers in stable COPD.
Methods.
Among 610 patients referred for NIV, we shortlisted those undergoing NIV versus oxygen therapy alone, excluding subjects with comorbidities or non-COPD conditions.
Sputum and blood samples were collected after 3 months of clinical stability and analyzed for levels of human neutrophil peptides (HNP), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha).
Patients underwent a two-year follow-up.
Unadjusted, propensity-matched, and pH-stratified analyses were performed.
Results.
Ninety-three patients were included (48 NIV, 45 oxygen), with analogous baseline features.
Sputum analysis showed similar HNP, IL-6, IL-10, and TNF-alpha levels (P>0.5).
Conversely, NIV group exhibited higher HNP and IL-6 systemic levels (P<0.001) and lower IL-10 concentrations (P<0.001).
Subjects undergoing NIV had a significant reduction of rehospitalizations during follow-up compared to oxygen group (P=0.005).
These findings were confirmed after propensity matching and pH stratification.
Conclusions.
These findings challenge prior paradigms based on the assumption that pulmonary inflammation is per se detrimental.
NIV beneficial impact on lung mechanics may overcome the potential unfavorable effects of an increased inflammatory state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Paone, Gregorino& Conti, Vittoria& Biondi-Zoccai, Giuseppe& De Falco, Elena& Chimenti, Isotta& Peruzzi, Mariangela…[et al.]. 2014. Long-Term Home Noninvasive Mechanical Ventilation Increases Systemic Inflammatory Response in Chronic Obstructive Pulmonary Disease: A Prospective Observational Study. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043613
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Paone, Gregorino…[et al.]. Long-Term Home Noninvasive Mechanical Ventilation Increases Systemic Inflammatory Response in Chronic Obstructive Pulmonary Disease: A Prospective Observational Study. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043613
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Paone, Gregorino& Conti, Vittoria& Biondi-Zoccai, Giuseppe& De Falco, Elena& Chimenti, Isotta& Peruzzi, Mariangela…[et al.]. Long-Term Home Noninvasive Mechanical Ventilation Increases Systemic Inflammatory Response in Chronic Obstructive Pulmonary Disease: A Prospective Observational Study. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043613
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043613
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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