Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals
المؤلفون المشاركون
Teixeira, Frederico
Mega, Cristina
Teixeira de Lemos, Edite
Fernandes, Rosa
Marques, Catarina
Gonçalves, Andreia
Fontes-Ribeiro, Carlos
Rodrigues-Santos, Paulo
Reis, Flávio
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-08
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This study aimed to evaluate the efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in preventing the deleterious effects of diabetes on the kidney in an animal model of type 2 diabetes mellitus; the Zucker diabetic fatty (ZDF) rat: 20-week-old rats were treated with sitagliptin (10 mg/kg bw/day) during 6 weeks.
Glycaemia and blood HbA 1c levels were monitored, as well as kidney function and lesions.
Kidney mRNA and/or protein content/distribution of DPP-IV, GLP-1, GLP-1R, TNF- α , IL-1 β , BAX, Bcl-2, and Bid were evaluated by RT-PCR and/or western blotting/immunohistochemistry.
Sitagliptin treatment improved glycaemic control, as reflected by the significantly reduced levels of glycaemia and HbA 1c (by about 22.5% and 1.2%, resp.) and ameliorated tubulointerstitial and glomerular lesions.
Sitagliptin prevented the diabetes-induced increase in DPP-IV levels and the decrease in GLP-1 levels in kidney.
Sitagliptin increased colocalization of GLP-1 and GLP-1R in the diabetic kidney.
Sitagliptin also decreased IL-1 β and TNF- α levels, as well as, prevented the increase of BAX/Bcl-2 ratio, Bid protein levels, and TUNEL-positive cells which indicates protective effects against inflammation and proapoptotic state in the kidney of diabetic rats, respectively.
In conclusion, sitagliptin might have a major role in preventing diabetic nephropathy evolution due to anti-inflammatory and antiapoptotic properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marques, Catarina& Mega, Cristina& Gonçalves, Andreia& Rodrigues-Santos, Paulo& Teixeira de Lemos, Edite& Teixeira, Frederico…[et al.]. 2014. Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043635
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marques, Catarina…[et al.]. Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043635
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marques, Catarina& Mega, Cristina& Gonçalves, Andreia& Rodrigues-Santos, Paulo& Teixeira de Lemos, Edite& Teixeira, Frederico…[et al.]. Sitagliptin Prevents Inflammation and Apoptotic Cell Death in the Kidney of Type 2 Diabetic Animals. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043635
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043635
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر