Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy
المؤلفون المشاركون
Jarr, Kai-Uwe
Chorianopoulos, Emmanuel
Nelles, Manfred
Katus, Hugo A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
TNF-like weak inducer of apoptosis (TWEAK) has been reported to predict mortality in patients with dilated cardiomyopathy.
However, whether it can be used as a biomarker for disease monitoring or rather represents a risk factor for disease progression remains unclear.
Aim of the Study.
To evaluate the potential of sTWEAK as a biomarker in patients with dilated cardiomyopathy.
Results.
We conducted a serial study of sTWEAK levels in 78 patients with dilated cardiomyopathy.
Soluble TWEAK levels predicted not only a combined mortality/heart transplantation endpoint after 4 years ( P = 0.0001 ), but also the risk for clinical deterioration ( P = 0.0001 ).
Compared to NT-proBNP, sTWEAK remained relatively stable in individual patients on follow-up indicating that inter- rather than intraindividual differences in sTWEAK levels predicted outcome.
Finally, neither did the scavenger receptor sCD163 correlate with sTWEAK levels nor did its determination add additional information on outcome in patients with dilated cardiomyopathy.
Conclusion.
Soluble TWEAK levels in patients with dilated cardiomyopathy may not be of value for disease monitoring but may represent a risk factor for disease progression and death.
Further research will be necessary to elucidate the exact role of sTWEAK as a potential modulator of immune response in the setting of dilated cardiomyopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jarr, Kai-Uwe& Nelles, Manfred& Katus, Hugo A.& Chorianopoulos, Emmanuel. 2014. Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jarr, Kai-Uwe…[et al.]. Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jarr, Kai-Uwe& Nelles, Manfred& Katus, Hugo A.& Chorianopoulos, Emmanuel. Inter- Not Intraindividual Differences in sTWEAK Levels Predict Functional Deterioration and Mortality in Patients with Dilated Cardiomyopathy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر