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Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study
المؤلفون المشاركون
Kheirandish-Gozal, Leila
Gileles-Hillel, Alex
Alonso-Álvarez, María Luz
Peris, Eduard
Cordero-Guevara, José Aurelio
Terán-Santos, Joaquin
Martinez, Mónica Gonzalez
Jurado-Luque, María José
Corral-Peñafiel, Jaime
Duran-Cantolla, Joaquin
Gozal, David
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities.
Aim.
To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables.
Methods.
In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4–15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw.
Plasma samples were assayed for multiple inflammatory markers.
Results.
204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST).
BMI, gender, and age were similar in OSA and no-OSA children.
Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA (i.e., AHI > 5/hrTST; P < 0.01 ) , while MCP-1 levels were associated with more prolonged nocturnal hypercapnia ( P < 0.001 ) .
Conclusion.
IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA.
This trial is registered with ClinicalTrials.gov NCT01322763.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gileles-Hillel, Alex& Alonso-Álvarez, María Luz& Kheirandish-Gozal, Leila& Peris, Eduard& Cordero-Guevara, José Aurelio& Terán-Santos, Joaquin…[et al.]. 2014. Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gileles-Hillel, Alex…[et al.]. Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gileles-Hillel, Alex& Alonso-Álvarez, María Luz& Kheirandish-Gozal, Leila& Peris, Eduard& Cordero-Guevara, José Aurelio& Terán-Santos, Joaquin…[et al.]. Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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