The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates
المؤلفون المشاركون
Zeher, Margit
Papp, Gabor
Szabo, Krisztina
Dezso, Balazs
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Recently, we revealed the importance of follicular helper T cells (TFH) in the pathogenesis of primary Sjögren’s syndrome (pSS).
In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on TFH and germinal center B cells.
We selected tissue blocks obtained from ten patients at the time of disease onset.
Detection of cell specific markers was performed with immunohistochemical and immunofluorescence stainings.
We evaluated patients’ clinical and laboratory features retrospectively and assessed the relation between disease course and early histopathological findings.
LSG biopsies were graded based on the extension and arrangement level of periductal inflammatory cell infiltrates.
TFH cell markers (CD84, PD-1, and Bcl-6) occurred predominantly in more organized structures with higher focus scores.
The coexpression of CD3 and Bcl-6 markers clearly identified TFH cells close to Bcl-6+ B cells with the typical formation of germinal centers.
Systemic features were developed later in the disease course only in patients with highly structured infiltrates and the presence of TFH cells.
Our observations suggest that the presence of TFH cells in LSGs at the disease onset may predict a more pronounced clinical course of pSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szabo, Krisztina& Papp, Gabor& Dezso, Balazs& Zeher, Margit. 2014. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szabo, Krisztina…[et al.]. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szabo, Krisztina& Papp, Gabor& Dezso, Balazs& Zeher, Margit. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر