Bisphenol A Alters β -hCG and MIF Release by Human Placenta: An In Vitro Study to Understand the Role of Endometrial Cells
المؤلفون المشاركون
Wasniewski, Tomasz
Szóstek, Anna Z.
Carotenuto, C.
Romagnoli, R.
Paulesu, Luana
Skarzynski, Dariusz J.
Ietta, Francesca
Mannelli, Chiara
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
A proper fetomaternal immune-endocrine cross-talk in pregnancy is fundamental for reproductive success.
This might be unbalanced by exposure to environmental chemicals, such as bisphenol A (BPA).
As fetoplacental contamination with BPA originates from the maternal compartment, this study investigated the role of the endometrium in BPA effects on the placenta.
To this end, in vitro decidualized stromal cells were exposed to BPA 1 nM, and their conditioned medium (diluted 1 : 2) was used on chorionic villous explants from human placenta.
Parallel cultures of placental explants were directly exposed to 0.5 nM BPA while, control cultures were exposed to the vehicle (EtOH 0.1%).
After 24–48 h, culture medium from BPA-treated and control cultures was assayed for concentration of hormone human Chorionic Gonadotropin (β-hCG) and cytokine Macrophage Migration Inhibitory Factor (MIF).
The results showed that direct exposure to BPA stimulated the release of both MIF and β-hCG.
These effects were abolished/diminished in placental cultures exposed to endometrial cell-conditioned medium.
GM-MS analysis revealed that endometrial cells retain BPA, thus reducing the availability of this chemical for the placenta.
The data obtained highlight the importance of in vitro models including the maternal component in reproducing the effects of environmental chemicals on human fetus/placenta.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mannelli, Chiara& Ietta, Francesca& Carotenuto, C.& Romagnoli, R.& Szóstek, Anna Z.& Wasniewski, Tomasz…[et al.]. 2014. Bisphenol A Alters β -hCG and MIF Release by Human Placenta: An In Vitro Study to Understand the Role of Endometrial Cells. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mannelli, Chiara…[et al.]. Bisphenol A Alters β -hCG and MIF Release by Human Placenta: An In Vitro Study to Understand the Role of Endometrial Cells. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mannelli, Chiara& Ietta, Francesca& Carotenuto, C.& Romagnoli, R.& Szóstek, Anna Z.& Wasniewski, Tomasz…[et al.]. Bisphenol A Alters β -hCG and MIF Release by Human Placenta: An In Vitro Study to Understand the Role of Endometrial Cells. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر