Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats
المؤلفون المشاركون
Mufti, Shagufta
Al-Maghrabi, Jaudah
Abdel Sattar, Essam
Ghareib, Salah A.
Mosli, Hisham A.
Gabr, Salah A.
Elberry, Ahmed A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-13
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Red onion scales (ROS) contain large amounts of flavonoids that are responsible for the reported antioxidant activity, immune enhancement, and anticancer property.
Atypical prostatic hyperplasia (APH) was induced in adult castrated Wistar rats by both s.c.
injection of testosterone (0.5 mg/rat/day) and by smearing citral on shaved skin once every 3 days for 30 days.
Saw palmetto (100 mg/kg) as a positive control and ROS suspension at doses of 75, 150, and 300 mg/kg/day were given orally every day for 30 days.
All medications were started 7 days after castration and along with testosterone and citral.
The HPLC profile of ROS methanolic extract displayed two major peaks identified as quercetin and quercetin-4′-β-O-D-glucoside.
Histopathological examination of APH-induced prostatic rats revealed evidence of hyperplasia and inflammation with cellular proliferation and reduced apoptosis Immunohistochemistry showed increased tissue expressions of IL-6, IL-8, TNF-α, IGF-1, and clusterin, while TGF-β1 was decreased, which correlates with the presence of inflammation.
Both saw palmetto and RO scale treatment have ameliorated these changes.
These ameliorative effects were more evident in RO scale groups and were dose dependent.
In conclusion, methanolic extract of ROS showed a protective effect against APH induced rats that may be attributed to potential anti-inflammatory and immunomodulatory effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elberry, Ahmed A.& Mufti, Shagufta& Al-Maghrabi, Jaudah& Abdel Sattar, Essam& Ghareib, Salah A.& Mosli, Hisham A.…[et al.]. 2014. Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elberry, Ahmed A.…[et al.]. Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elberry, Ahmed A.& Mufti, Shagufta& Al-Maghrabi, Jaudah& Abdel Sattar, Essam& Ghareib, Salah A.& Mosli, Hisham A.…[et al.]. Immunomodulatory Effect of Red Onion (Allium cepa Linn) Scale Extract on Experimentally Induced Atypical Prostatic Hyperplasia in Wistar Rats. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر