Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration
المؤلفون المشاركون
Kwaśny-Krochin, Beata
Wizner, Barbara
Klimek, Ewa
Surdacki, Andrzej
Korkosz, Mariusz
Fedak, Danuta
Kierzkowska, Izabella
Skalska, Anna
Grodzicki, Tomasz K.
Sulicka, Joanna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
To estimate endothelial dysfunction in patients with rheumatoid arthritis (RA) of short duration in relation to disease activity based on the assessment of 28 joints (DAS28).
Methods.
We studied 29 patients (22 women, mean age 41 (SD, 9) years) with RA of short duration and 29 healthy controls.
The RA subjects were divided into those with low (DAS28: 2.6–5.1, n=18) or high (DAS28>5.1, n=11) disease activity.
Exclusion criteria included clinically overt atherosclerosis and other coexistent diseases.
Biochemical markers of inflammatory activation and endothelial dysfunction were measured.
Results.
There were no significant intergroup differences in the majority of classical cardiovascular risk factors.
High-sensitivity C-reactive protein, tumor necrosis factor-α, and interleukin-6 were increased in RA subjects.
Compared to the controls, levels of soluble vascular cell adhesion molecule-1, von Willebrand factor, and pentraxin-3 were significantly elevated in RA subjects with low disease activity, exhibiting no further significant rises in those with high disease activity.
Asymmetric dimethyl-L-arginine, soluble E-selectin, monocyte chemotactic protein-1, and osteoprotegerin were increased only in RA patients with high disease activity.
Conclusions.
Our findings might suggest a dissociation of pathways governing generalized and joint-specific inflammatory reactions from those involved in endothelial activation and inflammation within the vascular wall.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klimek, Ewa& Skalska, Anna& Kwaśny-Krochin, Beata& Surdacki, Andrzej& Sulicka, Joanna& Korkosz, Mariusz…[et al.]. 2014. Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klimek, Ewa…[et al.]. Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klimek, Ewa& Skalska, Anna& Kwaśny-Krochin, Beata& Surdacki, Andrzej& Sulicka, Joanna& Korkosz, Mariusz…[et al.]. Differential Associations of Inflammatory and Endothelial Biomarkers with Disease Activity in Rheumatoid Arthritis of Short Duration. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر