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Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin
المؤلفون المشاركون
Pecháňová, Olga
Simko, Fedor
Repova Bednarova, Kristina
Krajcirovicova, Kristina
Celec, Peter
Kamodyova, Natalia
Kucharska, Jarmila
Gvozdjakova, Anna
Adamcova, Michaela
Paulis, Ludovit
Zorad, Stefan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Exposure of rats to continuous light attenuates melatonin production and results in hypertension development.
This study investigated whether hypertension induced by continuous light (24 hours/day) exposure induces heart and aorta remodelling and if these alterations are prevented by melatonin or angiotensin converting enzyme inhibitor captopril.
Four groups of 3-month-old male Wistar rats (10 per group) were treated as follows for six weeks: untreated controls, exposed to continuous light, light-exposed, and treated with either captopril (100 mg/kg/day) or melatonin (10 mg/kg/day).
Exposure to continuous light led to hypertension, left ventricular (LV) hypertrophy and fibrosis, and enhancement of the oxidative load in the LV and aorta.
Increase in systolic blood pressure by continuous light exposure was prevented completely by captopril and partially by melatonin.
Both captopril and melatonin reduced the wall thickness and cross-sectional area of the aorta and reduced the level of oxidative stress.
However, only captopril reduced LV hypertrophy development and only melatonin reduced LV hydroxyproline concentration in insoluble and total collagen in rats exposed to continuous light.
In conclusion, captopril prevented LV hypertrophy development in the continuous light-induced hypertension model, while only melatonin significantly reduced fibrosis.
This antifibrotic action of melatonin may be protective in hypertensive heart disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Simko, Fedor& Pecháňová, Olga& Repova Bednarova, Kristina& Krajcirovicova, Kristina& Celec, Peter& Kamodyova, Natalia…[et al.]. 2014. Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043742
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Simko, Fedor…[et al.]. Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043742
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Simko, Fedor& Pecháňová, Olga& Repova Bednarova, Kristina& Krajcirovicova, Kristina& Celec, Peter& Kamodyova, Natalia…[et al.]. Hypertension and Cardiovascular Remodelling in Rats Exposed to Continuous Light: Protection by ACE-Inhibition and Melatonin. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043742
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043742
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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