Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis
المؤلفون المشاركون
Bai, Jing
Zhong, Xiao-Ning
Liu, Jifeng
He, Zhiyi
Wei, Lianghong
Zheng, Xiaozhen
Zhang, Jianquan
Zhong, Wei
Zhong, Dengjun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-04
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations.
Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases.
Objective.
To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients with NCFB under steady state.
Methods.
The study involved an open-label design in 52 eligible Chinese patients with NCFB, who were assigned to control (receiving no treatment) and roxithromycin (receiving 150 mg/day for 6 months) groups.
At baseline and 6 months, the inflammatory markers such as interleukin- (IL-)8, neutrophil elastase (NE), matrix metalloproteinase- (MMP)9, hyaluronidase (HA), and type IV collagen in sputum were measured, along with the detection of dilated bronchus by throat computed tomography scan, and assessed the exacerbation.
Results.
Forty-three patients completed the study.
The neutrophil in the sputum was decreased in roxithromycin group compared with control ( P < 0.0 5 ) .
IL-8, NE, MMP-9, HA, and type IV collagen in sputum were also decreased in roxithromycin group compared with the control group (all P < 0.01 ) .
Airway thickness of dilated bronchus and exacerbation were reduced in roxithromycin group compared with the control (all P < 0.0 5 ) .
Conclusions.
Roxithromycin can reduce airway inflammation and airway thickness of dilated bronchus in patients with NCFB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jifeng& Zhong, Xiao-Ning& He, Zhiyi& Wei, Lianghong& Zheng, Xiaozhen& Zhang, Jianquan…[et al.]. 2014. Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jifeng…[et al.]. Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jifeng& Zhong, Xiao-Ning& He, Zhiyi& Wei, Lianghong& Zheng, Xiaozhen& Zhang, Jianquan…[et al.]. Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر