Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation
المؤلفون المشاركون
Salas, C. E.
Ralph, Maria Taciana
Nascimento, Danielle Cristina Oliveira
Lima-Filho, J. V.
Silva, Ayrles Fernanda Brandão
da Silva, Dayane Laíse
da Silva, Diogo Manoel Farias
Gomes-Filho, Manoel A.
Souza, Paulo Roberto Eleutério
Evêncio-Neto, Joaquim
Ramos, Márcio Viana
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The immunomodulatory properties of a mixture of cysteine peptidases (P1G10) obtained from the fruit lattice of Carica candamarcensis were investigated.
P1G10 was obtained from fresh latex samples by chromatography in a Sephadex column and initially administered to Swiss mice ( n = 5 ; 1 or 10 mg/kg) via i.p.
After 30 min, the mice were injected with carrageenan (0.5 mg/mouse) or heat-killed S.
Typhimurium (107 CFU/mL; 100°C/30 min) into the peritoneal cavity.
Afterwards, two animal groups were i.p.
administered with P1G10 ( n = 6 ; 1, 5, or 10 mg/Kg) or PBS 24 hours prior to challenge with live S.
Typhimurium (107 CFU/mL).
P1G10 stimulated the proliferation of circulating neutrophils and lymphocytes, 6 h after injection of carrageenan or heat-killed bacteria, respectively.
Furthermore, survival after infection was dose-dependent and reached 60% of the animal group.
On the other hand, control mice died 1–3 days after infection.
The examination of mRNA transcripts in liver cells 24 h after infection confirmed fold variation increases of 5.8 and 4.8 times on average for IL-1 and COX-2, respectively, in P1G10 pretreated mice but not for TNF-α, IL-10, γ-IFN and iNOS, for which the results were comparable to untreated animals.
These data are discussed in light of previous reports.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ralph, Maria Taciana& Silva, Ayrles Fernanda Brandão& da Silva, Dayane Laíse& Nascimento, Danielle Cristina Oliveira& da Silva, Diogo Manoel Farias& Gomes-Filho, Manoel A.…[et al.]. 2014. Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ralph, Maria Taciana…[et al.]. Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ralph, Maria Taciana& Silva, Ayrles Fernanda Brandão& da Silva, Dayane Laíse& Nascimento, Danielle Cristina Oliveira& da Silva, Diogo Manoel Farias& Gomes-Filho, Manoel A.…[et al.]. Peptidases from Latex of Carica candamarcensis Upregulate COX-2 and IL-1 mRNA Transcripts against Salmonella enterica ser. Typhimurium-Mediated Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر