Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine
المؤلفون المشاركون
Brown, Kathryn S.
Gong, Huiyu
Frey, Mark R.
Pope, Brock
Golden, Matthew
Martin, Katerina
Obey, Mitchel
McElroy, Steven J.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Premature infants are commonly subject to intestinal inflammation.
Since the human small intestine does not reach maturity until term gestation, premature infants have a unique challenge, as either acute or chronic inflammation may alter the normal development of the intestinal tract.
Tumor necrosis factor (TNF) has been shown to acutely alter goblet cell numbers and villus length in adult mice.
In this study we tested the effects of TNF on villus architecture and epithelial cells at different stages of development of the immature small intestine.
Methods.
To examine the effects of TNF-induced inflammation, we injected acute, brief, or chronic exposures of TNF in neonatal and juvenile mice.
Results.
TNF induced significant villus blunting through a TNF receptor-1 (TNFR1) mediated mechanism, leading to loss of villus area.
This response to TNFR1 signaling was altered during intestinal development, despite constant TNFR1 protein expression.
Acute TNF-mediated signaling also significantly decreased Paneth cells.
Conclusions.
Taken together, the morphologic changes caused by TNF provide insight as to the effects of inflammation on the developing intestinal tract.
Additionally, they suggest a mechanism which, coupled with an immature immune system, may help to explain the unique susceptibility of the immature intestine to inflammatory diseases such as NEC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brown, Kathryn S.& Gong, Huiyu& Frey, Mark R.& Pope, Brock& Golden, Matthew& Martin, Katerina…[et al.]. 2014. Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brown, Kathryn S.…[et al.]. Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brown, Kathryn S.& Gong, Huiyu& Frey, Mark R.& Pope, Brock& Golden, Matthew& Martin, Katerina…[et al.]. Tumor Necrosis Factor Induces Developmental Stage-Dependent Structural Changes in the Immature Small Intestine. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر