Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis
المؤلفون المشاركون
Dimisianos, Nikolaos
Rodi, Maria
Kalavrizioti, Dimitra
Georgiou, Vasileios
Papathanasopoulos, Panagiotis
Mouzaki, Athanasia
المصدر
Multiple Sclerosis International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
MS patients show a remarkable heterogeneity in their response to disease modifying treatments.
Given the need for early treatment initiation and the diversity of available options, a predictive marker that indicates good or poor response to treatment is highly desirable.
Objective.
To find a biomarker for treatment response to IFNβ among pro- and anti-inflammatory cytokines.
Materials and Methods.
IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and TGF-β1 levels were measured in serum and CSF of 43 patients with RR-MS who were followed up for a mean period of 5.3 years.
Thirty-five patients received IFNβ treatment and were divided into good responders (GR, n = 19) and poor responders (PR, n = 16).
The remaining 8 patients showed a very favorable outcome and remained untreated (noRx).
Results.
GR had significantly higher serum baseline levels of IL-17A than PR and significantly higher serum levels of IL-17A, IFN-γ, TNF-α, and IL-2 than noRx.
PR had significantly higher IFN-γ serum levels than noRx.
No significant differences were observed in serum levels of IL-6, IL-4, IL-10, and TGF-β1 or the levels of all cytokines measured in CSF between the 3 groups of patients.
Conclusions.
Baseline serum levels of IL-17A can be used as a biomarker of IFNβ treatment response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. 2014. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dimisianos, Nikolaos…[et al.]. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046598
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر