Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis

المؤلفون المشاركون

Dimisianos, Nikolaos
Rodi, Maria
Kalavrizioti, Dimitra
Georgiou, Vasileios
Papathanasopoulos, Panagiotis
Mouzaki, Athanasia

المصدر

Multiple Sclerosis International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-07-22

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

MS patients show a remarkable heterogeneity in their response to disease modifying treatments.

Given the need for early treatment initiation and the diversity of available options, a predictive marker that indicates good or poor response to treatment is highly desirable.

Objective.

To find a biomarker for treatment response to IFNβ among pro- and anti-inflammatory cytokines.

Materials and Methods.

IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and TGF-β1 levels were measured in serum and CSF of 43 patients with RR-MS who were followed up for a mean period of 5.3 years.

Thirty-five patients received IFNβ treatment and were divided into good responders (GR, n = 19) and poor responders (PR, n = 16).

The remaining 8 patients showed a very favorable outcome and remained untreated (noRx).

Results.

GR had significantly higher serum baseline levels of IL-17A than PR and significantly higher serum levels of IL-17A, IFN-γ, TNF-α, and IL-2 than noRx.

PR had significantly higher IFN-γ serum levels than noRx.

No significant differences were observed in serum levels of IL-6, IL-4, IL-10, and TGF-β1 or the levels of all cytokines measured in CSF between the 3 groups of patients.

Conclusions.

Baseline serum levels of IL-17A can be used as a biomarker of IFNβ treatment response.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. 2014. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dimisianos, Nikolaos…[et al.]. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046598

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1046598