Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats
المؤلفون المشاركون
Fillet, Marianne
Pawluski, Jodi L.
van Donkelaar, Eva
Abrams, Zipporah
Houbart, Virginie
Charlier, Thierry D.
Steinbusch, H. W. M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Selective serotonin reuptake inhibitor medications are one of the most common treatments for mood disorders.
In humans, these medications are taken orally, usually once per day.
Unfortunately, administration of antidepressant medications in rodent models is often through injection, oral gavage, or minipump implant, all relatively stressful procedures.
The aim of the present study was to investigate how administration of the commonly used SSRI, fluoxetine, via a wafer cookie, compares to fluoxetine administration using an osmotic minipump, with regards to serum drug levels and hippocampal plasticity.
For this experiment, adult female Sprague-Dawley rats were divided over the two administration methods: (1) cookie and (2) osmotic minipump and three fluoxetine treatment doses: 0, 5, or 10 mg/kg/day.
Results show that a fluoxetine dose of 5 mg/kg/day, but not 10 mg/kg/day, results in comparable serum levels of fluoxetine and its active metabolite norfluoxetine between the two administration methods.
Furthermore, minipump administration of fluoxetine resulted in higher levels of cell proliferation in the granule cell layer (GCL) at a 5 mg dose compared to a 10 mg dose.
Synaptophysin expression in the GCL, but not CA3, was significantly lower after fluoxetine treatment, regardless of administration method.
These data suggest that the administration method and dose of fluoxetine can differentially affect hippocampal plasticity in the adult female rat.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pawluski, Jodi L.& van Donkelaar, Eva& Abrams, Zipporah& Houbart, Virginie& Fillet, Marianne& Steinbusch, H. W. M.…[et al.]. 2014. Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats. Neural Plasticity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046625
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pawluski, Jodi L.…[et al.]. Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats. Neural Plasticity No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046625
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pawluski, Jodi L.& van Donkelaar, Eva& Abrams, Zipporah& Houbart, Virginie& Fillet, Marianne& Steinbusch, H. W. M.…[et al.]. Fluoxetine Dose and Administration Method Differentially Affect Hippocampal Plasticity in Adult Female Rats. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046625
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046625
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر