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Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats
المؤلفون المشاركون
Chen, Peng-zhi
Jiang, Hui-hui
Wen, Bo
Ren, Shuan-cheng
Chen, Yang
Ji, Wei-gang
Hu, Bo
Zhang, Jun
Xu, Fenglian
Zhu, Zhi-ru
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Accumulated soluble amyloid beta- (Aβ-) induced aberrant neuronal network activity may directly contribute to cognitive deficits, which are the most outstanding characteristics of Alzheimer’s disease (AD).
The entorhinal cortex (EC) is one of the earliest affected brain regions in AD.
Impairments of EC neurons are responsible for the cognitive deficits in AD.
However, little effort has been made to investigate the effects of soluble Aβ on the discharge properties of EC neurons in vivo.
The present study was designed to examine the effects of soluble Aβ1−42 on the discharge properties of EC neurons, using in vivo extracellular single unit recordings.
The protective effects of gastrodin (GAS) were also investigated against Aβ1−42-induced alterations in EC neuronal activities.
The results showed that the spontaneous discharge of EC neurons was increased by local application of soluble Aβ1−42 and that GAS can effectively reverse Aβ1−42-induced facilitation of spontaneous discharge in a concentration-dependent manner.
Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons.
Our study suggested that GAS may provide neuroprotective effects on Aβ1−42-induced hyperactivity in EC neurons of rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Peng-zhi& Jiang, Hui-hui& Wen, Bo& Ren, Shuan-cheng& Chen, Yang& Ji, Wei-gang…[et al.]. 2014. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Peng-zhi…[et al.]. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Peng-zhi& Jiang, Hui-hui& Wen, Bo& Ren, Shuan-cheng& Chen, Yang& Ji, Wei-gang…[et al.]. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046677
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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