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Nociceptive Neurons Differentially Express Fast and Slow T-Type Ca2+ Currents in Different Types of Diabetic Neuropathy
المؤلفون المشاركون
Khomula, Eugen V.
Borisyuk, Anya L.
Viatchenko-Karpinski, Viacheslav Y.
Briede, Andrea
Belan, Pavel V.
Voitenko, Nana V.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
T-type Ca2+ channels are known as important participants of nociception and their remodeling contributes to diabetes-induced alterations of pain sensation.
In this work we have established that about 30% of rat nonpeptidergic thermal C-type nociceptive (NTCN) neurons of segments L4–L6 express a slow T-type Ca2+ current (T-current) while a fast T-current is expressed in the other 70% of these neurons.
Streptozotocin-induced diabetes in young rats resulted in thermal hyperalgesia, hypoalgesia, or normalgesia 5-6 weeks after the induction.
Our results show that NTCN neurons obtained from hyperalgesic animals do not express the slow T-current.
Meanwhile, the fraction of neurons expressing the slow T-current did not significantly change in the hypo- and normalgesic diabetic groups.
Moreover, the peak current density of fast T-current was significantly increased only in the neurons of hyperalgesic group.
In contrast, the peak current density of slow T-current was significantly decreased in the hypo- and normalgesic groups.
Experimental diabetes also resulted in a depolarizing shift of steady-state inactivation of fast T-current in the hyperalgesic group and slow T-current in the hypo- and normalgesic groups.
We suggest that the observed changes may contribute to expression of different types of peripheral diabetic neuropathy occurring during the development of diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khomula, Eugen V.& Borisyuk, Anya L.& Viatchenko-Karpinski, Viacheslav Y.& Briede, Andrea& Belan, Pavel V.& Voitenko, Nana V.. 2014. Nociceptive Neurons Differentially Express Fast and Slow T-Type Ca2+ Currents in Different Types of Diabetic Neuropathy. Neural Plasticity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046750
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khomula, Eugen V.…[et al.]. Nociceptive Neurons Differentially Express Fast and Slow T-Type Ca2+ Currents in Different Types of Diabetic Neuropathy. Neural Plasticity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046750
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khomula, Eugen V.& Borisyuk, Anya L.& Viatchenko-Karpinski, Viacheslav Y.& Briede, Andrea& Belan, Pavel V.& Voitenko, Nana V.. Nociceptive Neurons Differentially Express Fast and Slow T-Type Ca2+ Currents in Different Types of Diabetic Neuropathy. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046750
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046750
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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