Improved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme
المؤلفون المشاركون
Benjamin, Linus C.
Horsley, Patrick J.
Silva, Thomaz
Wilcox, Shea
Amalaseelan, Julan
Dwyer, Patrick
Tahir, Abdul M. R.
Hill, Jacques
Last, Andrew
Hansen, Carmen
McLachlan, Craig S.
Lee, Yvonne L.
McKay, Michael J.
Shakespeare, Thomas P.
Aherne, Noel J.
المصدر
Neurology Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-19
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
Glioblastoma multiforme (GBM) is optimally treated by maximal debulking followed by combined chemoradiation.
Intensity modulated radiation therapy (IMRT) is gaining widespread acceptance in other tumour sites, although evidence to support its use over three-dimensional conformal radiation therapy (3DCRT) in the treatment of gliomas is currently lacking.
We examined the survival outcomes for patients with GBM treated with IMRT and Temozolomide.
Methods and Materials.
In all, 31 patients with GBM were treated with IMRT and 23 of these received chemoradiation with Temozolomide.
We correlated survival outcomes with patient functional status, extent of surgery, radiation dose, and use of chemotherapy.
Results.
Median survival for all patients was 11.3 months, with a median survival of 7.2 months for patients receiving 40.05 Gray (Gy) and a median survival of 17.4 months for patients receiving 60 Gy.
Conclusions.
We report one of the few series of IMRT in patients with GBM.
In our group, median survival for those receiving 60 Gy with Temozolomide compared favourably to the combined therapy arm of the largest randomised trial of chemoradiation versus radiation to date (17.4 months versus 14.6 months).
We propose that IMRT should be considered as an alternative to 3DCRT for patients with GBM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aherne, Noel J.& Benjamin, Linus C.& Horsley, Patrick J.& Silva, Thomaz& Wilcox, Shea& Amalaseelan, Julan…[et al.]. 2014. Improved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme. Neurology Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aherne, Noel J.…[et al.]. Improved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme. Neurology Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1046809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aherne, Noel J.& Benjamin, Linus C.& Horsley, Patrick J.& Silva, Thomaz& Wilcox, Shea& Amalaseelan, Julan…[et al.]. Improved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر