Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients
المؤلفون المشاركون
Deflorio, Cristina
Onesti, Emanuela
Lauro, Clotilde
Tartaglia, Giorgio
Giovannelli, Aldo
Limatola, Cristina
Inghilleri, Maurizio
Grassi, Francesca
المصدر
Neurology Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Denervated muscles undergo fibrillations due to spontaneous activation of voltage-gated sodium (Na+) channels generating action potentials.
Fibrillations also occur in patients with amyotrophic lateral sclerosis (ALS).
Riluzole, the only approved drug for ALS treatment, blocks voltage-gated Na+ channels, but its effects on muscle Na+ channels and fibrillations are yet poorly characterized.
Using patch-clamp technique, we studied riluzole effect on Na+ channels in cultured myotubes from ALS patients.
Needle electromyography was used to study fibrillation potentials (Fibs) in ALS patients during riluzole treatment and after one week of suspension.
Patients were clinically characterized in all recording sessions.
In myotubes, riluzole (1 μM, a therapeutic concentration) reduced Na+ current by 20%.
The rate of rise and amplitude of spikes evoked by depolarizing stimuli were also reduced.
Fibs were detected in all patients tested during riluzole treatment and riluzole washout had no univocal effect.
Our study indicates that, in human myotubes, riluzole partially blocks Na+ currents and affects action potentials but does not prevent firing.
In line with this in vitro finding, muscle Fibs in ALS patients appear to be largely unaffected by riluzole.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deflorio, Cristina& Onesti, Emanuela& Lauro, Clotilde& Tartaglia, Giorgio& Giovannelli, Aldo& Limatola, Cristina…[et al.]. 2014. Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients. Neurology Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046810
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deflorio, Cristina…[et al.]. Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients. Neurology Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046810
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deflorio, Cristina& Onesti, Emanuela& Lauro, Clotilde& Tartaglia, Giorgio& Giovannelli, Aldo& Limatola, Cristina…[et al.]. Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046810
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046810
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر