First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population
المؤلفون المشاركون
Teixeira, Cláudia
Tejera, Eduardo
Martins, Helena
Pereira, António Tomé
Costa-Pereira, Altamiro
Rebelo, Irene
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions.
Materials and Methods.
Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 to June 2013.
Logistic regression-based predictive models were developed for prediction of PE based on maternal characteristics, crown-rump length (CRL), nuchal translucency thickness (NT), and maternal serum levels of pregnancy-associated plasma protein-A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (free β-hCG).
Results.
At a false-positive rate of 5/10%, the detection rate for early-onset (EO-PE) and late-onset (LO-PE) PE was 31.4/45.7% and 29.5/35.2%, respectively.
Although both forms of PE were associated with decreased PAPP-A, logistic regression analysis revealed significant contributions from maternal factors, free β-hCG, CRL, and NT, but not PAPP-A, for prediction of PE.
Conclusion.
Our findings support that both clinical forms of EO-PE and LO-PE can be predicted using a combination of maternal history and biomarkers assessed at first trimester aneuploidy screening.
However, detection rates were modest, suggesting that models need to be improved with additional markers not included in the current aneuploidy screening programs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teixeira, Cláudia& Tejera, Eduardo& Martins, Helena& Pereira, António Tomé& Costa-Pereira, Altamiro& Rebelo, Irene. 2014. First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population. Obstetrics and Gynecology International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046897
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teixeira, Cláudia…[et al.]. First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population. Obstetrics and Gynecology International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046897
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teixeira, Cláudia& Tejera, Eduardo& Martins, Helena& Pereira, António Tomé& Costa-Pereira, Altamiro& Rebelo, Irene. First Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population. Obstetrics and Gynecology International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046897
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046897
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر