Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress
المؤلفون المشاركون
Monda, Marcellino
Lombardi, Angela
Martin, Giuseppe A.
Porcelli, Marina
Stiuso, Paola
Sperlongano, P.
Scognamiglio, Ilaria
Caraglia, Michele
Messina, Giovanni
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk.
Young overweight men (n=20), without metabolic syndrome, were placed in a 3-week residential program on a low-fat diet and moderate aerobic exercise.
In each subject, pre- and postintervention fasting blood were collected for evaluating levels of serum lipids, and oxidative stress markers.
Using subject sera and cardiomyocyte (H9C2) culture systems, we measured heat shock protein 27 and 90 expression, lipid accumulation, and oxidative stress marker levels.
After 3-weeks of diet, significant reductions (P<0.05) in body mass index, serum lipids and lipid ratios, and oxidative markers were recorded.
In vitro, we observed that the addition of postintervention sera increased H9C2 cell number and reduced HSP27 and 90 expression, mitochondrial superoxide anion, and lipid accumulation with a parallel increase in nitric oxide (NO) production (all P<0.01).
At the same time, postintervention sera decreased human liver hepatocellular carcinoma cell line (HepG-2) proliferation, lipid accumulation, oxidative stress, and extracellular-signal-regulated kinases (ERK1/2) activity.
Lifestyle modification in young overweight men, without metabolic syndrome, could ameliorate cardiocyte survival and reduce hepatocellular carcinoma cell proliferation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Monda, Marcellino& Messina, Giovanni& Scognamiglio, Ilaria& Lombardi, Angela& Martin, Giuseppe A.& Sperlongano, P.…[et al.]. 2014. Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046927
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Monda, Marcellino…[et al.]. Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046927
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Monda, Marcellino& Messina, Giovanni& Scognamiglio, Ilaria& Lombardi, Angela& Martin, Giuseppe A.& Sperlongano, P.…[et al.]. Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046927
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046927
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر