New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart
المؤلفون المشاركون
Frati, Giacomo
Ikeda, Yoshiyuki
Sciarretta, Sebastiano
Nagarajan, Narayani
Rubattu, Speranza
Sadoshima, Junichi
Volpe, Massimo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The heart is highly sensitive to the aging process.
In the elderly, the heart tends to become hypertrophic and fibrotic.
Stiffness increases with ensuing systolic and diastolic dysfunction.
Aging also affects the cardiac response to stress.
At the molecular level, the aging process is associated with accumulation of damaged proteins and organelles, partially due to defects in protein quality control systems.
The accumulation of dysfunctional and abnormal mitochondria is an important pathophysiological feature of the aging process, which is associated with excessive production of reactive oxygen species.
Mitochondrial fusion and fission and mitochondrial autophagy are crucial mechanisms for maintaining mitochondrial function and preserving energy production.
In particular, mitochondrial fission allows for selective segregation of damaged mitochondria, which are afterward eliminated by autophagy.
Unfortunately, recent evidence indicates that mitochondrial dynamics and autophagy are progressively impaired over time, contributing to the aging process.
This suggests that restoration of these mechanisms could delay organ senescence and prevent age-associated cardiac diseases.
Here, we discuss the current understanding of the close relationship between mitochondrial dynamics, mitophagy, oxidative stress, and aging, with a particular focus on the heart.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ikeda, Yoshiyuki& Sciarretta, Sebastiano& Nagarajan, Narayani& Rubattu, Speranza& Volpe, Massimo& Frati, Giacomo…[et al.]. 2014. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046964
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ikeda, Yoshiyuki…[et al.]. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046964
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ikeda, Yoshiyuki& Sciarretta, Sebastiano& Nagarajan, Narayani& Rubattu, Speranza& Volpe, Massimo& Frati, Giacomo…[et al.]. New Insights into the Role of Mitochondrial Dynamics and Autophagy during Oxidative Stress and Aging in the Heart. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046964
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046964
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر