Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction
المؤلفون المشاركون
Hsu, Chien-Ning
Huang, Li-Tung
Lee, Chien-Te
Tain, You-Lin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-20
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Nitric oxide (NO) deficiency is involved in the development of hypertension, a condition that can originate early in life.
We examined whether NO deficiency contributed to programmed hypertension in offspring from mothers with calorie-restricted diets and whether melatonin therapy prevented this process.
We examined 3-month-old male rat offspring from four maternal groups: untreated controls, 50% calorie-restricted (CR) rats, controls treated with melatonin (0.01% in drinking water), and CR rats treated with melatonin (CR + M).
The effect of melatonin on nephrogenesis was analyzed using next-generation sequencing.
The CR group developed hypertension associated with elevated plasma asymmetric dimethylarginine (ADMA, a nitric oxide synthase inhibitor), decreased L-arginine, decreased L-arginine-to-ADMA ratio (AAR), and decreased renal NO production.
Maternal melatonin treatment prevented these effects.
Melatonin prevented CR-induced renin and prorenin receptor expression.
Renal angiotensin-converting enzyme 2 protein levels in the M and CR + M groups were also significantly increased by melatonin therapy.
Maternal melatonin therapy had long-term epigenetic effects on global gene expression in the kidneys of offspring.
Conclusively, we attributed these protective effects of melatonin on CR-induced programmed hypertension to the reduction of plasma ADMA, restoration of plasma AAR, increase of renal NO level, alteration of renin-angiotensin system, and epigenetic changes in numerous genes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tain, You-Lin& Huang, Li-Tung& Hsu, Chien-Ning& Lee, Chien-Te. 2014. Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1046990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tain, You-Lin…[et al.]. Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1046990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tain, You-Lin& Huang, Li-Tung& Hsu, Chien-Ning& Lee, Chien-Te. Melatonin Therapy Prevents Programmed Hypertension and Nitric Oxide Deficiency in Offspring Exposed to Maternal Caloric Restriction. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1046990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1046990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر