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Reduced Oxidative Stress Contributes to the Lipid Lowering Effects of Isoquercitrin in Free Fatty Acids Induced Hepatocytes
المؤلفون المشاركون
Shang, Jing
Hassan, Waseem
Rongyin, Gao
Daoud, Abdelkader
Ding, Lin
Wang, Lulu
Liu, Jun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-22
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Oxidative stress interferes with hepatic lipid metabolism at various levels ranging from benign lipid storage to so-called second hit of inflammation activation.
Isoquercitrin (IQ) is widely present flavonoid but its effects on hepatic lipid metabolism remain unknown.
We used free fatty acids (FFA) induced lipid overload and oxidative stress model in two types of liver cells and measured cell viability, intracellular lipids, and reactive oxygen species (ROS) within hepatocytes.
In addition, Intracellular triglycerides (TG), superoxide dismutase (SOD), and malondialdehyde (MDA) were examined.
A novel in vitro model was used to evaluate correlation between lipid lowering and antioxidative activities.
Furthermore, 34 major cytokines and corresponding ROS levels were analyzed in FFA/LPS induced coculture model between hepatocytes and Kupffer cells.
At molecular level AMPK pathway was elucidated.
We showed that IQ attenuated FFA induced lipid overload and ROS within hepatocytes.
Further, IQ reversed FFA induced increase in intracellular TG SOD and MDA.
It was shown that antioxidative activity of IQ correlates with its lipid lowering potentials.
IQ reversed major proinflammatory cytokines and oxidative stress in FFA/LPS induced coculture model.
Finally, AMPK pathway was found responsible for metabolic benefits at molecular level.
IQ strikingly manifests antioxidative and related lipid lowering activities in hepatocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Waseem& Rongyin, Gao& Daoud, Abdelkader& Ding, Lin& Wang, Lulu& Liu, Jun…[et al.]. 2014. Reduced Oxidative Stress Contributes to the Lipid Lowering Effects of Isoquercitrin in Free Fatty Acids Induced Hepatocytes. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Waseem…[et al.]. Reduced Oxidative Stress Contributes to the Lipid Lowering Effects of Isoquercitrin in Free Fatty Acids Induced Hepatocytes. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1047006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Waseem& Rongyin, Gao& Daoud, Abdelkader& Ding, Lin& Wang, Lulu& Liu, Jun…[et al.]. Reduced Oxidative Stress Contributes to the Lipid Lowering Effects of Isoquercitrin in Free Fatty Acids Induced Hepatocytes. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1047006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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