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Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System
المؤلفون المشاركون
Maruf, Abdullah Al
O'Brien, Peter John
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Flutamide (FLU) is a competitive antagonist of the androgen receptor which has been reported to induce severe liver injury in some patients.
Several experimental models suggested that an episode of inflammation during drug treatment predisposes animals to tissue injury.
The molecular cytotoxic mechanisms of FLU in isolated rat hepatocytes using an in vitro oxidative stress inflammation system were investigated in this study.
When a nontoxic hydrogen peroxide (H2O2) generating system (glucose/glucose oxidase) with peroxidase or iron(II) [Fe(II)] (to partly simulate in vivo inflammation) was added to the hepatocytes prior to the addition of FLU, increases in FLU-induced cytotoxicity and lipid peroxidation (LPO) were observed that were decreased by 6-N-propyl-2-thiouracil or deferoxamine, respectively.
N-Acetylcysteine decreased FLU-induced cytotoxicity in this system.
Potent antioxidants, for example, Trolox ((±)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), resveratrol (3,5,4′-trihydroxy-trans-stilbene), and DPPD (N,N′-diphenyl-1,4-phenylenediamine) also significantly decreased FLU-induced cytotoxicity and LPO and increased mitochondrial membrane potential (MMP) and glutathione (GSH) levels in the H2O2 generating system with peroxidase.
TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl), a known reactive oxygen species (ROS) scavenger and superoxide dismutase mimetic, also significantly decreased toxicity caused by FLU in this system.
These results raise the possibility that the presence or absence of inflammation may be another susceptibility factor for drug-induced hepatotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maruf, Abdullah Al& O'Brien, Peter John. 2014. Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047023
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maruf, Abdullah Al& O'Brien, Peter John. Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047023
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maruf, Abdullah Al& O'Brien, Peter John. Flutamide-Induced Cytotoxicity and Oxidative Stress in an In Vitro Rat Hepatocyte System. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047023
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047023
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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