Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients
المؤلفون المشاركون
Ienco, Elena Caldarazzo
LoGerfo, Annalisa
Chico, Lucia
Borgia, Loredana
Petrozzi, Lucia
Rocchi, Anna
D'Amelio, Antonia
Carlesi, Cecilia
Mancuso, Michelangelo
Siciliano, Gabriele
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oxidative stress involvement has been strongly hypothesized among the possible pathogenic mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS).
The intracellular redox balance is finely modulated by numerous complex mechanisms critical for cellular functions, among which the nuclear factor erythroid-derived 2-like 2 (NFE2L2/Nrf2) pathways.
We genotyped, in a cohort of ALS patients ( n = 145 ) and healthy controls ( n = 168 ) , three SNPs in Nrf2 gene promoter: −653 A/G, −651 G/A, and −617 C/A and evaluated, in a subset ( n = 73 ) of patients, advanced oxidation protein products (AOPP), iron-reducing ability of plasma (FRAP), and plasma thiols (-SH) as oxidative damage peripheral biomarkers.
Nrf2 polymorphisms were not different among patients and controls.
Increased levels of AOPP ( P < 0.05 ) and decreased levels of FRAP ( P < 0.001 ) have been observed in ALS patients compared with controls, but no difference in -SH values was found.
Furthermore, no association was found between biochemical markers of redox balance and Nrf2 polymorphisms.
These data confirm an altered redox balance in ALS and indicate that, while being abnormally modified compared to controls, the oxidative stress biomarkers assessed in this study are independent from the −653 A/G, −651 G/A, and −617 C/A Nrf2 SNPs in ALS patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
LoGerfo, Annalisa& Chico, Lucia& Borgia, Loredana& Petrozzi, Lucia& Rocchi, Anna& D'Amelio, Antonia…[et al.]. 2014. Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047033
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
LoGerfo, Annalisa…[et al.]. Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1047033
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
LoGerfo, Annalisa& Chico, Lucia& Borgia, Loredana& Petrozzi, Lucia& Rocchi, Anna& D'Amelio, Antonia…[et al.]. Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1047033
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047033
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر