Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases
المؤلفون المشاركون
Cai, Lu
Liu, Yucheng
Sun, Jian
Li, Fengsheng
Miao, Xiao
Wang, Yonggang
Liu, Quan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide despite advances in its prevention and management.
A comprehensive understanding of factors which contribute to CVD is required in order to develop more effective treatment options.
Dysregulation of epigenetic posttranscriptional modifications of histones in chromatin is thought to be associated with the pathology of many disease models, including CVD.
Histone acetyltransferases (HATs) and deacetylases (HDACs) are regulators of histone lysine acetylation.
Recent studies have implicated a fundamental role of reversible protein acetylation in the regulation of CVDs such as hypertension, pulmonary hypertension, diabetic cardiomyopathy, coronary artery disease, arrhythmia, and heart failure.
This reversible acetylation is governed by enzymes that HATs add or HDACs remove acetyl groups respectively.
New evidence has revealed that histone acetylation regulators blunt cardiovascular and related disease states in certain cellular processes including myocyte hypertrophy, apoptosis, fibrosis, oxidative stress, and inflammation.
The accumulating evidence of the detrimental role of histone acetylation in cardiac disease combined with the cardioprotective role of histone acetylation regulators suggests that the use of histone acetylation regulators may serve as a novel approach to treating the millions of patients afflicted by cardiac diseases worldwide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yonggang& Miao, Xiao& Liu, Yucheng& Li, Fengsheng& Liu, Quan& Sun, Jian…[et al.]. 2014. Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yonggang…[et al.]. Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yonggang& Miao, Xiao& Liu, Yucheng& Li, Fengsheng& Liu, Quan& Sun, Jian…[et al.]. Dysregulation of Histone Acetyltransferases and Deacetylases in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر