Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
المؤلفون المشاركون
Lugo-Huitrón, Rafael
Reyes Ocampo, Jazmin
González-Esquivel, Dinora
Jiménez-Anguiano, Anabel
Ríos, Camilo
Ugalde Muñiz, Perla
Pineda, Benjamín
Pérez-de la Cruz, Verónica
Pedraza-Chaverri, José
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
The kynurenine pathway (KP) is the main route of tryptophan degradation whose final product is NAD+.
The metabolism of tryptophan can be altered in ageing and with neurodegenerative process, leading to decreased biosynthesis of nicotinamide.
This fact is very relevant considering that tryptophan is the major source of body stores of the nicotinamide-containing NAD+ coenzymes, which is involved in almost all the bioenergetic and biosynthetic metabolism.
Recently, it has been proposed that endogenous tryptophan and its metabolites can interact and/or produce reactive oxygen species in tissues and cells.
This subject is of great importance due to the fact that oxidative stress, alterations in KP metabolites, energetic deficit, cell death, and inflammatory events may converge each other to enter into a feedback cycle where each one depends on the other to exert synergistic actions among them.
It is worth mentioning that all these factors have been described in aging and in neurodegenerative processes; however, has so far no one established any direct link between alterations in KP and these factors.
In this review, we describe each kynurenine remarking their redox properties, their effects in experimental models, their alterations in the aging process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reyes Ocampo, Jazmin& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Ugalde Muñiz, Perla& Jiménez-Anguiano, Anabel& Pineda, Benjamín…[et al.]. 2014. Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-1047076
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reyes Ocampo, Jazmin…[et al.]. Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-22.
https://search.emarefa.net/detail/BIM-1047076
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reyes Ocampo, Jazmin& Lugo-Huitrón, Rafael& González-Esquivel, Dinora& Ugalde Muñiz, Perla& Jiménez-Anguiano, Anabel& Pineda, Benjamín…[et al.]. Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-22.
https://search.emarefa.net/detail/BIM-1047076
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1047076
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر